Acute Thymic Involution and Mechanisms for Recovery
نویسندگان
چکیده
منابع مشابه
Genetic regulation of thymic involution.
In this review, we have summarized our work using combined complex statistical genetics, bioinformatics, and functional genomics to determine the genetic basis of the age-related thymic involution in C57BL/6J X DBA/2J recombinant inbred mice and the parental B6 and D2 mice. We have shown that these mice provided a valuable genetic model that can permit resampling of thymuses from different aged...
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It is well known that age-related involution (shrinkage) of the thymus (a central cellular immune organ) results in decreased output of naïve T cells [1]. The insufficiency of naïve T cells significantly reduces the T cell receptor repertoire diversity, thereby leading to immunosenescence. However, the deleterious effects of thymic involution extend beyond diminished output. It also increases t...
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ژورنال
عنوان ژورنال: Archivum Immunologiae et Therapiae Experimentalis
سال: 2017
ISSN: 0004-069X,1661-4917
DOI: 10.1007/s00005-017-0462-x